Effective May 20, 2024, Clinical Pathology Laboratories (CPL) will be implementing a change in the clinical reporting range (CRR) of the Thyroglobulin Antibody assay. CRR is the range of values an instrument can report as a quantitative result. Values greater than or less than the CRR are reported as greater than (>) or less than (<).


10-4000 IU/mL 15-4000 IU/mL
Current CRR New CRR

Thyroglobulin (Tg) is produced in the thyroid gland and is a main component in the lumen of the thyroid follicle. In synergy with the enzyme thyroid-specific peroxidase (TPO), Tg has an essential function in the iodination of L‑tyrosine and in the formation of the thyroid hormones T4 and T3.1

Elevated serum concentrations of antibodies against Thyroglobulin Antibody are found in subjects with autoimmunity-based thyroiditis.2,3 The frequency of thyroglobulin antibodies is approximately 50‑80% in subjects with autoimmune-thyroiditis, including Hashimoto’s disease, and approximately 30‑50% in individuals with Graves’ disease.3,4,5,6 The anti‑Tg assay can also provide useful information for monitoring the course of Hashimoto’s thyroiditis and for differential diagnosis.3,7 This includes cases of suspected autoimmune thyroiditis of unknown origin with negative anti‑TPO test results,8,9 and to distinguish Hashimoto’s thyroiditis from nontoxic nodular goiter or from other forms of thyroiditis.4


Order Codes affected by CRR change:

Thyroglobulin AB RFLX EIA vs LCMS 4447
Thyroglobulin AB 4516
Thyroid Antibody Group (TPO + TG) 4610
Thyroglobulin, Quantitative and Antibody 4927
 Name  Order Code



  1. Mansourian AR. Metabolic pathways of tetraidothyronine and triidothyronine production by thyroid gland: a review of articles. Pak J Biol Sci 2011;14(1):1-12.
  2. Ruf J, Ferrand M, Durand-Gorde JM, et al. Significance of thyroglobulin antibodies cross-reactive with thyroperoxidase (TGPO antibodies) in individual patients and immunized mice. Clin Exp Immunol 1993;92(1):65-72.
  3. Thomas L. Thyroid function. Thyroglobulin antibodies. In: Thomas L (ed.). Deutsch: Labor und Diagnose. TH-Books, Frankfurt. 5th edition 1998:1043. English: Clinical Laboratory Diagnosis. 1st edition 1998:1021.
  4. Slatosky J, Shipton B, Wahba H. Thyroiditis: differential diagnosis and management. Am Fam Physician 2000;61(4):1047-1052.
  5. Garber JR, Cobin RH, Gharib H, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and The American Thyroid Association. Thyroid
  6. Iddah MA, Macharia BN. Autoimmune thyroid disorders. ISRN Endocrinol 2013:509764.
  7. Schmeltz LR, Blevins TC, Aronoff SL, et al. Anatabine supplementation decreases thyroglobulin antibodies in patients with chronic lymphocytic autoimmune (Hashimoto’s) thyroiditis: A randomized controlled clinical trial. J Clin Endocrinol Metab 2014;99:E137-E142.
  8. Feldt-Rasmussen U. Analytical and clinical performance goals for testing autoantibodies to hyroperoxidase, thyroglobulin, and thyrotropin receptor. Clin Chem 1996;42(1):160-163.